Altered subthalamo-pallidal synchronisation in parkinsonian dyskinesias.

Parkinsonian Pattern Transduction by Gpi

It is hypothesised that Parkinson’s disease is explained as a change in the pattern of synchronisation of discharges between neurons within the subthalamo-pallidal-thalamo-cortical circuit. By simulating a single GPi neuron receiving non-synchronous and oscillatory inputs the conditions required for the generation of normal and Parkinsonian patterns are determined.

Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus-Subthalamic Nucleus Network under External Input

Hypokinetic symptoms of Parkinson's disease are usually associated with excessively strong oscillations and synchrony in the beta frequency band. The origin of this synchronized oscillatory dynamics is being debated. Cortical circuits may be a critical source of excessive beta in Parkinson's disease. However, subthalamo-pallidal circuits were also suggested to be a substantial component in gene...

Decreased Firing Rates and Altered Firing Patterns Drug-Related Dyskinesias in Parkinson's Disease: Internal Pallidal Neuronal Activity During Mild

A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys.

The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei, a moderate number of labeled neurons were found within the subthalamic nucleus (STN) in control...

Internal pallidal neuronal activity during mild drug-related dyskinesias in Parkinson's disease: decreased firing rates and altered firing patterns.

The neuronal basis of hyperkinetic movement disorders has long been unclear. We now test the hypothesis that changes in the firing pattern of neurons in the globus pallidus internus (GPi) are related to dyskinesias induced by low doses of apomorphine in patients with advanced Parkinson's disease (PD). During pallidotomy for advanced PD, the activity of single neurons was studied both before and...